This could change any time, sinceDOMO is still in its Beta stage. This is a simple Pro/Con for the two weapons.

Fist

Pros: + Physical Critical Attack

+ Max Hp
+ Decent Attack
+ Can utilize all Power Attacks to its fullest
+ Don't have to wait till lvl 30+ for an AoE skill
+ Ignore def skills(goldceo.com)
+ Less general MP cost and Cool Down time vs Staff

Cons: - Slightly under Staff in terms of attack
- Can't use Staff skills except for Menditation

Staff

Pros: + Accuracy

+ Evasion
+ Slightly higher attack than fist
+ Can use some key Power Attacks skills while staff is equipped
+ Very powerful multiple hit skills

Cons: - Unless you're an AGI MA, evade is useless
- No AoE skills till lvl 30+
- Longer Cool Down and more MP cost

If you have any question else or wanna buy DOMO gold and DOMO powerleveling, just contact us.^^

 

Source.